NEPH1 is a member of the NEPH protein family, which includes NEPH2 (KIRREL3, MIM607761) and NEPH3 (KIRREL2, MIM607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766). NEPH1 is expressed in filtration slits of kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration of blood (Sellin et al., 2003). [supplied by OMIM][6]
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID15144186.
the NEPH protein family of transmembrane proteins, which includes NEPH1 (KIRREL) and NEPH3 (KIRREL2). The NEPH proteins can interact with nephrin and CASK
David Whittington 1,023 41.7 Labour Margaret Blake 891 36.3 Labour Stephen Kirrelly 766 31.2 Labour Michael Paris 751 30.6 OWL Neil Pye 480 19.5 Liberal Democrats
KIRREL2 is a member of the NEPH protein family, which includes NEPH1 (KIRREL) and NEPH2 (KIRREL3). GRCh38: Ensembl release 89: ENSG00000126259 – Ensembl
Nephrin has been shown to interact with: CASK, CD2AP, CDH3 and CTNND1, FYN, KIRREL, and NPHS2. Nephrin was first identified in 1998 by Karl Tryggvason and
