| Bromoderma | |
|---|---|
| Other names | Bromoderma tuberosum |
| Specialty | Dermatology |
Bromoderma is a skin condition characterized by an eruption of papules and pustules on the skin.[1]:โ135โ It is caused by hypersensitivity to bromides, such as those found in certain drugs. There is at least one reported case of bromoderma caused by excessive consumption of a soft drink (Ruby Red Squirt) containing brominated vegetable oil.[2]
Signs and symptoms
editThe disease's symptoms can range from a mild acneiform rash with papules and pustules to more severe conditions like panniculitis, ulcers, and vegetative nodules, also referred to as tuberous or vegetating bromoderma. Lesions usually affect the lower limbs, scalp, and face.[3][4]
Causes
editOne could characterize bromoderma as a kind of delayed hypersensitivity reaction, even though its pathogenesis is still unknown.[5] Lesions can develop as soon as eight days after the medicine is first administered, but they typically do so after a prolonged period of use. High sebaceous gland concentrations on the skin are typically the site of lesions.[6]
Diagnosis
editSkin lesions, a patient's history of using bromide, and the healing of lesions following drug withdrawal can all be used to make a diagnosis.[7]
See also
editReferences
edit- ^ James WD, Berger T, Elston D (2006). Andrews' Diseases of the Skin: Clinical Dermatology (10thย ed.). Philadelphia: Saunders Elsevier. ISBNย 978-0-7216-2921-6.
- ^ Jih DM, Khanna V, Somach SC (May 2003). "Bromoderma after excessive ingestion of Ruby Red Squirt". The New England Journal of Medicine. 348 (19): 1932โ1934. doi:10.1056/NEJM200305083481921. PMIDย 12736294.
- ^ Nabatame, Shin; Saito, Yoshiaki; Sakuma, Hiroshi; Komaki, Hirofumi; Nakagawa, Eiji; Sugai, Kenji; Sasaki, Masayuki; Uchiyama, Kentaro; Kosaka, Maki (2010). "Bromoderma in a patient with migrating partial seizures in infancy". Epilepsy Research. 91 (2โ3). Elsevier BV: 283โ288. doi:10.1016/j.eplepsyres.2010.07.008. ISSNย 0920-1211. PMIDย 20674275. S2CIDย 3408441.
- ^ Anzai, Saburo; Fujiwara, Sakuhei; Inuzuka, Miki (2003). "Bromoderma". International Journal of Dermatology. 42 (5). Wiley: 370โ371. doi:10.1046/j.1365-4362.2003.01734.x. ISSNย 0011-9059. PMIDย 12755974. S2CIDย 221812784.
- ^ Maffeis, Laura; Musolino, Maria Carmela; Cambiaghi, Stefano (2008). "Single-plaque vegetating bromoderma". Journal of the American Academy of Dermatology. 58 (4). Elsevier BV: 682โ684. doi:10.1016/j.jaad.2007.08.011. ISSNย 0190-9622. PMIDย 18342716.
- ^ Hoefel, Isadora da Rosa; Camozzato, Fernanda Oliveira; Hagemann, Laura Netto; Rhoden, Deise Louise Bohn; Kiszewski, Ana Elisa (2016). "Bromoderma in an infant". Anais Brasileiros de Dermatologia. 91 (5 suppl 1). FapUNIFESP (SciELO): 17โ19. doi:10.1590/abd1806-4841.20165013. ISSNย 0365-0596. PMCย 5324981. PMIDย 28300882.
- ^ Bel, Susana; Bartralot, Ramรณn; Garcรญa, Daniel; Aparicio, Gloria; Castells, Antonio (2001). "Vegetant Bromoderma in an Infant". Pediatric Dermatology. 18 (4). Wiley: 336โ338. doi:10.1046/j.1525-1470.2001.01954.x. ISSNย 0736-8046. PMIDย 11576411. S2CIDย 19631925.
Further reading
edit- Paloni, Giulia; Mattei, Ilaria; Ravagnan, Enrico; Cutrone, Mario (2013). "Infantile Bromoderma". The Journal of Pediatrics. 163 (3). Elsevier BV: 920โ920.e1. doi:10.1016/j.jpeds.2013.03.071. ISSNย 0022-3476. PMIDย 23651770.
