Fotemustine
Clinical data
Trade namesMustophoran
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • AU: D
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
Identifiers
  • (RS)-diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}
    ethyl)phosphonate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.158.792 Edit this at Wikidata
Chemical and physical data
FormulaC9H19ClN3O5P
Molar mass315.69 g·mol−1
3D model (JSmol)
  • O=P(OCC)(OCC)C(NC(=O)N(N=O)CCCl)C
  • InChI=1S/C9H19ClN3O5P/c1-4-17-19(16,18-5-2)8(3)11-9(14)13(12-15)7-6-10/h8H,4-7H2,1-3H3,(H,11,14) checkY
  • Key:YAKWPXVTIGTRJH-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Fotemustine is a nitrosourea alkylating agent used in the treatment of metastatic melanoma. It is available in Europe but has not been approved by the United States FDA.[1] A study[2] has shown that fotemustine produces improved response rates but does not increase survival (over dacarbazine in the treatment of disseminated cutaneous melanoma. Median survival was 7.3 months with fotemustine versus 5.6 months with DTIC (P=.067). There was also toxicity prevalence in fotemustine arm. The main toxicity was grade 3 to 4 neutropenia (51% with fotemustine v 5% with DTIC) and thrombocytopenia (43% v 6%, respectively).

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  1. ^ Menaa, Farid (2013). "Latest Approved Therapies for Metastatic Melanoma: What Comes Next?". Journal of Skin Cancer. 2013: 1–10. doi:10.1155/2013/735282. PMC 3595667. PMID 23533766.
  2. ^ Avril MF, Aamdal S, Grob JJ, Hauschild A, Mohr P, Bonerandi JJ, Weichenthal M (March 2004). "Fotemustine Compared With Dacarbazine in Patients With Disseminated Malignant Melanoma: A Phase III Study". Journal of Clinical Oncology. 22 (6): 1118–25. doi:10.1200/JCO.2004.04.165. PMID 15020614.
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List of chemotherapeutic agents

Chlorambucil Chlormethine Chlorozotocin Cyclophosphamide Dacarbazine Fotemustine Ifosfamide Lomustine Melphalan Melphalan flufenamide Mitobronitol Nimustine

Nitrosourea

(Aranose) Carmustine (BCNU, BiCNU) Chlorozotocin Ethylnitrosourea (ENU) Fotemustine Lomustine (CCNU) Nimustine N-Nitroso-N-methylurea (NMU) Ranimustine (MCNU)

Laboratoires Servier

(Mediaxal) Carbutamide (Glucidoral) Daflon 500 Fenspiride (Pneumorel) Fotemustine (Muphoran) Fusafungine (Locabiotal) Gliclazide (Diamicron) Indapamide

Melanoma

to remission. Some of these drugs are dacarbazine, temozolomide, and fotemustine. Combinations of drugs are also used and, in some cases, present higher

ATC code L01

Carmustine L01AD02 Lomustine L01AD03 Semustine L01AD04 Streptozocin L01AD05 Fotemustine L01AD06 Nimustine L01AD07 Ranimustine L01AD08 Uramustine L01AG01 Etoglucid

FOLFIRI

(Melphalan flufenamide) Prednimustine Uramustine Nitrosoureas: Carmustine Fotemustine Lomustine (Semustine) Nimustine Ranimustine Streptozocin Alkyl sulfonates:

Chemotherapy

(NMU), carmustine (BCNU), lomustine (CCNU) and semustine (MeCCNU), fotemustine and streptozotocin (STZ). Tetrazines include dacarbazine, mitozolomide

Lifileucel

(Melphalan flufenamide) Prednimustine Uramustine Nitrosoureas: Carmustine Fotemustine Lomustine (Semustine) Nimustine Ranimustine Streptozocin Alkyl sulfonates: