CD44 📖 Wikipedia

CD44
Struktur yang tersedia PDB Pencarian ortolog: PDBe RCSB Daftar kode ID PDB 1POZ, 1UUH, 2I83, 4PZ3, 4PZ4
Pengidentifikasi
Alias	CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CD44 molecule (Indian blood group)
ID Eksternal	OMIM: 107269; MGI: 88338; HomoloGene: 508; GeneCards: CD44; OMA:CD44 - orthologs
Pola ekspresi RNA Bgee Manusia Tikus (ortologi) Ekspresi tertinggi di parotid gland stromal cell of endometrium vulva gingival epithelium skin of thigh penis manusia skin of abdomen Tendon Achilles skin of hip Pulau Langerhans Ekspresi tertinggi di Gigi geraham Granulosit kalvaria dermis submandibular gland epithelium of lens tibiofemoral joint parotid gland endothelial cell of lymphatic vessel body of femur Referensi data ekspresi selengkapnya BioGPS Data ekspresi referensi lebih lanjut
Ontologi gen Fungsi molekuler collagen binding Ikatan protein plasma hyaluronic acid binding cytokine receptor activity transmembrane signaling receptor activity Komponen seluler komponen integral membran badan Golgi macrophage migration inhibitory factor receptor complex membran focal adhesion membran sel integral component of plasma membrane cell surface extracellular exosome sitosol secretory granule membrane membran plasma apikal lamellipodium membrane cell projection microvillus membran plasma basolateral Proses biologis negative regulation of cysteine-type endopeptidase activity involved in apoptotic process monocyte aggregation positive regulation of heterotypic cell-cell adhesion hyaluronan catabolic process negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator interferon-gamma-mediated signaling pathway extracellular matrix disassembly extracellular matrix organization negative regulation of apoptotic process cellular response to fibroblast growth factor stimulus positive regulation of peptidyl-serine phosphorylation cartilage development Adhesi sel negative regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of ERK1 and ERK2 cascade positive regulation of peptidyl-tyrosine phosphorylation cell-matrix adhesion positive regulation of monocyte aggregation leukocyte migration neutrophil degranulation wound healing, spreading of cells regulation of lamellipodium morphogenesis cell-cell adhesion inflammatory response Migrasi sel T cell activation positive regulation of kinase activity Sumber:Amigo / QuickGO
Ortologi Spesies Manusia Tikus Entrez 960 12505 Ensembl ENSG00000026508 ENSMUSG00000005087 UniProt P16070 P15379 RefSeq (mRNA) NM_000610 NM_001001389 NM_001001390 NM_001001391 NM_001001392 NM_001202555 NM_001202556 NM_001202557 NM_001039150 NM_001039151 NM_001177785 NM_001177786 NM_001177787 NM_009851 RefSeq (protein) NP_000601 NP_001001389 NP_001001390 NP_001001391 NP_001001392 NP_001189484 NP_001189485 NP_001189486 NP_001034239 NP_001034240 NP_001171256 NP_001171257 NP_001171258 NP_033981 Location (UCSC) n/a n/a PubMed search [1] [2]
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

CD44 adalah ekspresi gen berupa glikoprotein transmembran yang banyak mengalami variasi proteolitik.^[3] Isoform berupa CD44v banyak terdapat pada sel sekretori di sekitar kelenjar prostat, sedangkan ekspresi CD44s ditemukan pada seluruh jenis sel epitelial. Terganggunya ekspresi CD44 akan memungkinkan pertumbuhan tumor dan invasinya menjadi kanker.

Pada kanker prostat, hormon kalsitonin berperan sebagai faktor pertumbuhan parakrin yang menginduksi ekspresi varian CD44 yaitu CD44v7-10 melalui lintasan protein kinase A dan p38. CD44v7-10 memiliki daya cerap lebih besar terhadap fibronektin daripada senyawa hialuronan yang biasa dicerapnya,^[4] dan mengaktivasi lintasan MAPK.

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