Prednimustine
Clinical data
Trade namesMostarina, Sterecyst
Other namesEORTC 1502; Leo 1031; NSC 134087; Prednisolone 21-(4-(4-(bis(2-chloroethyl)-amino)phenyl)butanoate); 11ฮฒ,17ฮฑ-Dihydroxy-3,20-dioxopregna-1,4-dien-21-yl 4-{4-[bis(2-chloroethyl)amino]-phenyl}butanoate
ATC code
Identifiers
  • [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.044.904 Edit this at Wikidata
Chemical and physical data
FormulaC35H45Cl2NO6
Molar mass646.65ย gยทmolโˆ’1
3D model (JSmol)
  • C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)COC(=O)CCCc4ccc(cc4)N(CCCl)CCCl)O)CCC5=CC(=O)C=C[C@]35C)O
  • InChI=1S/C35H45Cl2NO6/c1-33-14-12-26(39)20-24(33)8-11-27-28-13-15-35(43,34(28,2)21-29(40)32(27)33)30(41)22-44-31(42)5-3-4-23-6-9-25(10-7-23)38(18-16-36)19-17-37/h6-7,9-10,12,14,20,27-29,32,40,43H,3-5,8,11,13,15-19,21-22H2,1-2H3/t27-,28-,29-,32+,33-,34-,35-/m0/s1ย โ˜’N
  • Key:HFVNWDWLWUCIHC-GUPDPFMOSA-Nย โ˜’N
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Prednimustine, sold under the brand names Mostarina and Sterecyst, is a medication which is used in chemotherapy in the treatment of leukemias and lymphomas.[1][2][3] It is the ester formed from two other drugs, prednisolone and chlorambucil.[1][2][3] Rarely, it has been associated with myoclonus.[4]

See also

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References

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  1. ^ a b Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp.ย 1012โ€“. ISBNย 978-1-4757-2085-3.
  2. ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp.ย 868โ€“. ISBNย 978-3-88763-075-1.
  3. ^ a b Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp.ย 230โ€“. ISBNย 978-94-011-4439-1.
  4. ^ Monnerat C, Gander M, Leyvraz S (January 1997). "A rare case of prednimustine-induced myoclonus". Journal of the National Cancer Institute. 89 (2): 173โ€“174. doi:10.1093/jnci/89.2.173. PMIDย 8998190.

๐Ÿ“š Artikel Terkait di Wikipedia

Cortisol

Prednazoline Prednicarbate (prednisolone ethylcarbonate propionate) Prednimustine Prednisolamate (prednisolone diethylaminoacetate) Prednisolone esters

ATC code L01

L01AA05 Chlormethine L01AA06 Ifosfamide L01AA07 Trofosfamide L01AA08 Prednimustine L01AA09 Bendamustine L01AA10 Melphalan flufenamide L01AB01 Busulfan

Nadofaragene firadenovec

(Ifosfamide# Trofosfamide) Chlorambucil# Melphalan (Melphalan flufenamide) Prednimustine Uramustine Nitrosoureas: Carmustine Fotemustine Lomustine (Semustine)

Cyclophosphamide

(Ifosfamide# Trofosfamide) Chlorambucil# Melphalan (Melphalan flufenamide) Prednimustine Uramustine Nitrosoureas: Carmustine Fotemustine Lomustine (Semustine)

Cisplatin

(Ifosfamide# Trofosfamide) Chlorambucil# Melphalan (Melphalan flufenamide) Prednimustine Uramustine Nitrosoureas: Carmustine Fotemustine Lomustine (Semustine)

Prednisone

Prednazoline Prednicarbate (prednisolone ethylcarbonate propionate) Prednimustine Prednisolamate (prednisolone diethylaminoacetate) Prednisolone esters

Fluorouracil

(Ifosfamide# Trofosfamide) Chlorambucil# Melphalan (Melphalan flufenamide) Prednimustine Uramustine Nitrosoureas: Carmustine Fotemustine Lomustine (Semustine)

Olutasidenib

(Ifosfamide# Trofosfamide) Chlorambucil# Melphalan (Melphalan flufenamide) Prednimustine Uramustine Nitrosoureas: Carmustine Fotemustine Lomustine (Semustine)