SHANK1 📖 Wikipedia

SHANK1
Pengidentifikasi
Alias	SHANK1, SPANK-1, SSTRIP, synamon, SH3 and multiple ankyrin repeat domains 1
ID Eksternal	OMIM: 604999; MGI: 3613677; HomoloGene: 22949; GeneCards: SHANK1; OMA:SHANK1 - orthologs
Pola ekspresi RNA
	Ekspresi tertinggi di
	anterior cingulate cortex; ; right frontal lobe; ; Korteks prefrontal; ; Amigdala; ; right hemisphere of cerebellum; ; primary visual cortex; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; hippocampus proper; ; middle temporal gyrus;
	Ekspresi tertinggi di
	Korteks prefrontal; ; primary motor cortex; ; lobus temporalis; ; subiculum; ; cingulate gyrus; ; Amigdala; ; lateral geniculate nucleus; ; piriform cortex; ; primary visual cortex; ; medial dorsal nucleus;
	Referensi data ekspresi selengkapnya
	n/a
Ontologi gen
Fungsi molekuler	somatostatin receptor binding; SH3 domain binding; ankyrin repeat binding; scaffold protein binding; protein C-terminus binding; Ikatan protein plasma; synaptic receptor adaptor activity; pengikatan protein identik; ionotropic glutamate receptor binding; signaling receptor complex adaptor activity; protein-containing complex binding;
Komponen seluler	sitoplasma; postsynaptic membrane; membran; dendritic spine; sinapsis; excitatory synapse; intracellular anatomical structure; NMDA selective glutamate receptor complex; Sambungan sel; Dendrit; neuron projection; ionotropic glutamate receptor complex; postsynaptic density; sitosol; membran sel; Schaffer collateral - CA1 synapse; glutamatergic synapse; neuron spine;
Proses biologis	Diferensiasi sel; olfactory behavior; associative learning; neuromuscular process controlling balance; negative regulation of actin filament bundle assembly; positive regulation of dendritic spine development; perkembangan sistem saraf; regulation of AMPA receptor activity; dendritic spine morphogenesis; vocalization behavior; adult behavior; long-term memory; synapse maturation; positive regulation of excitatory postsynaptic potential; perilaku sosial; pembiasaan; determination of affect; righting reflex; protein localization to synapse; protein-containing complex assembly; postsynapse organization; Sinaptogenesis; brain morphogenesis; synaptic assembly at neuromuscular junction; positive regulation of synaptic transmission, glutamatergic; long-term potentiation; postsynaptic density assembly;
	Sumber:Amigo / QuickGO
Ortologi
	50944
	243961
	ENSG00000161681
	ENSMUSG00000038738
	Q9Y566
	D3YZU1
	NM_016148
	NM_001034115
	NP_057232
	NP_001029287
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

SH3 dan beberapa ankyrin ulangi domain protein 1 adalah protein yang pada manusia dikodekan oleh gen SHANK1.^[3]^[4]

Interaksi

sunting

SHANK1 telah diketahui berinteraksi dengan:

ARHGEF7,^[5]
BAIAP2,^[6]
DNM2,^[7]
SPTAN1,^[8] dan
Reseptor Somatostatin 2.

Referensi

sunting

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zitzer H, Hönck HH, Bächner D, Richter D, Kreienkamp HJ (January 2000). "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain". J Biol Chem. 274 (46): 32997–3001. doi:10.1074/jbc.274.46.32997. PMID 10551867. Pemeliharaan CS1: DOI bebas tanpa ditandai (link)
^ "Entrez Gene: SHANK1 SH3 and multiple ankyrin repeat domains 1".
^ Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, Kim E (May 2003). "The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42". J. Biol. Chem. 278 (21): 19220–9. doi:10.1074/jbc.M301052200. PMID 12626503. Pemeliharaan CS1: DOI bebas tanpa ditandai (link)
^ Soltau M, Richter D, Kreienkamp HJ (Dec 2002). "The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42". Mol. Cell. Neurosci. 21 (4): 575–83. doi:10.1006/mcne.2002.1201. PMID 12504591.
^ Okamoto PM, Gamby C, Wells D, Fallon J, Vallee RB (Dec 2001). "Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton". J. Biol. Chem. 276 (51): 48458–65. doi:10.1074/jbc.M104927200. PMC 2715172. PMID 11583995. Pemeliharaan CS1: DOI bebas tanpa ditandai (link)
^ Böckers TM, Mameza MG, Kreutz MR, Bockmann J, Weise C, Buck F, Richter D, Gundelfinger ED, Kreienkamp HJ (October 2001). "Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin". J. Biol. Chem. 276 (43): 40104–12. doi:10.1074/jbc.M102454200. PMID 11509555. Pemeliharaan CS1: DOI bebas tanpa ditandai (link)

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10551867-3] Zitzer H, Hönck HH, Bächner D, Richter D, Kreienkamp HJ (January 2000). "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain". J Biol Chem. 274 (46): 32997–3001. doi:10.1074/jbc.274.46.32997. PMID 10551867. Pemeliharaan CS1: DOI bebas tanpa ditandai (link)

[entrez-4] "Entrez Gene: SHANK1 SH3 and multiple ankyrin repeat domains 1".

[pmid12626503-5] Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, Kim E (May 2003). "The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42". J. Biol. Chem. 278 (21): 19220–9. doi:10.1074/jbc.M301052200. PMID 12626503. Pemeliharaan CS1: DOI bebas tanpa ditandai (link)

[pmid12504591-6] Soltau M, Richter D, Kreienkamp HJ (Dec 2002). "The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42". Mol. Cell. Neurosci. 21 (4): 575–83. doi:10.1006/mcne.2002.1201. PMID 12504591.

[pmid11583995-7] Okamoto PM, Gamby C, Wells D, Fallon J, Vallee RB (Dec 2001). "Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton". J. Biol. Chem. 276 (51): 48458–65. doi:10.1074/jbc.M104927200. PMC 2715172. PMID 11583995. Pemeliharaan CS1: DOI bebas tanpa ditandai (link)

[pmid11509555-8] Böckers TM, Mameza MG, Kreutz MR, Bockmann J, Weise C, Buck F, Richter D, Gundelfinger ED, Kreienkamp HJ (October 2001). "Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin". J. Biol. Chem. 276 (43): 40104–12. doi:10.1074/jbc.M102454200. PMID 11509555. Pemeliharaan CS1: DOI bebas tanpa ditandai (link)

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SHANK1 📖 Wikipedia

Interaksi

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