DPYSL2 📖 Wikipedia

DPYSL2
Struktur yang tersedia
PDB	Pencarian ortolog: PDBe RCSB
Daftar kode ID PDB
	2GSE, 2VM8
Pengidentifikasi
Alias	DPYSL2, CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2, dihydropyrimidinase like 2
ID Eksternal	OMIM: 602463; MGI: 1349763; HomoloGene: 74392; GeneCards: DPYSL2; OMA:DPYSL2 - orthologs
Pola ekspresi RNA
	Ekspresi tertinggi di
	inferior ganglion of vagus nerve; ; pars reticulata; ; subthalamic nucleus; ; pars compacta; ; superior vestibular nucleus; ; external globus pallidus; ; pons; ; cerebellar vermis; ; lateral nuclear group of thalamus; ; paraflocculus of cerebellum;
	Ekspresi tertinggi di
	paraventricular nucleus of hypothalamus; ; globus pallidus; ; anterior amygdaloid area; ; habenula; ; medial geniculate nucleus; ; dorsomedial hypothalamic nucleus; ; ventral tegmental area; ; medial dorsal nucleus; ; anterior horn of spinal cord; ; subiculum;
	Referensi data ekspresi selengkapnya
	Data ekspresi referensi lebih lanjut
Ontologi gen
Fungsi molekuler	microtubule binding; dihydropyrimidinase activity; Ikatan protein plasma; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; hydrolase activity; pengikatan protein identik;
Komponen seluler	sitoplasma; sitosol; membran; extracellular exosome; Mikrotubulus; Sitoskeleton; membran sel;
Proses biologis	regulation of neuron differentiation; Diferensiasi sel; Endositosis; regulation of axon extension; perkembangan sistem saraf; multicellular organism development; brain development; cytoskeleton organization; nucleobase-containing compound metabolic process; signal transduction; axon guidance; pyrimidine nucleobase catabolic process;
	Sumber:Amigo / QuickGO
Ortologi
	1808
	12934
	ENSG00000092964
	ENSMUSG00000022048
	Q16555
	O08553
	NM_001386; NM_001197293; NM_001244604
	NM_009955; NM_001378767
	NP_001184222; NP_001231533; NP_001377
	NP_034085; NP_001365696
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Protein terkait dihydropyrimidinase 2 adalah enzim yang pada manusia dikodekan oleh gen DPYSL2.^[3]^[4]

Interaksi

sunting

DPYSL2 telah terbukti memiliki interaksi dengan CRMP1,^[5] alpha 1^[6] dan NUMB.

Referensi

sunting

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.
^ "Entrez Gene: DPYSL2 dihydropyrimidinase-like 2".
^ Leung, Thomas; Ng Yvonne; Cheong Albert; Ng Chong Han; Tan Ivan; Hall Christine; Lim Louis (Dec 2002). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. 532 (3). Netherlands: 445–9. doi:10.1016/S0014-5793(02)03736-5. ISSN 0014-5793. PMID 12482610.
^ Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; Yamaguchi Tomoya; Matsuura Yoshiharu; Kamiguchi Hiroyuki; Kaibuchi Kozo (Sep 2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. 5 (9). England: 819–26. doi:10.1038/ncb1039. ISSN 1465-7392. PMID 12942088.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8973361-3] Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.

[entrez-4] "Entrez Gene: DPYSL2 dihydropyrimidinase-like 2".

[pmid12482610-5] Leung, Thomas; Ng Yvonne; Cheong Albert; Ng Chong Han; Tan Ivan; Hall Christine; Lim Louis (Dec 2002). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. 532 (3). Netherlands: 445–9. doi:10.1016/S0014-5793(02)03736-5. ISSN 0014-5793. PMID 12482610.

[pmid12942088-6] Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; Yamaguchi Tomoya; Matsuura Yoshiharu; Kamiguchi Hiroyuki; Kaibuchi Kozo (Sep 2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. 5 (9). England: 819–26. doi:10.1038/ncb1039. ISSN 1465-7392. PMID 12942088.

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DPYSL2 📖 Wikipedia

Interaksi

Referensi

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