This article is about the amino acid. For the group of cholesterol lowering drugs, see Statin.
Statine
Names
IUPAC name
(3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid
Identifiers
3D model (JSmol)
Abbreviations AHMHA, Sta
ChEBI
ChemSpider
ECHA InfoCard 100.161.428 Edit this at Wikidata
UNII
  • InChI=1S/C8H17NO3/c1-5(2)3-6(9)7(10)4-8(11)12/h5-7,10H,3-4,9H2,1-2H3,(H,11,12)/t6-,7-/m0/s1
    Key: DFVFTMTWCUHJBL-BQBZGAKWSA-N
  • N[C@@H](CC(C)C)[C@@H](O)CC(O)=O
Properties
C8H17NO3
Molar mass 175.228 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Statine is a gamma amino acid that occurs twice in the sequence of pepstatin, a protease inhibitor that is active against pepsin and other acid proteases.[1] It is thought to be responsible for the inhibitory activity of pepstatin because it mimics the tetrahedral transition state of peptide catalysis.[2]

References

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  1. ^ Umezawa, H.; Aoyagi, T.; Morishima, H.; Matsuzaki, M.; Hamada, M.; Takeuchi, T. (1970). "Pepstatin, a new pepsin inhibitor produced by Actinomycetes". The Journal of Antibiotics. 23 (5): 259–262. doi:10.7164/antibiotics.23.259. PMID 4912600.
  2. ^ Marciniszyn Jr, J.; Hartsuck, J. A.; Tang, J. (1976). "Mode of inhibition of acid proteases by pepstatin". The Journal of Biological Chemistry. 251 (22): 7088–7094. doi:10.1016/S0021-9258(17)32945-9. PMID 993206.

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📚 Artikel Terkait di Wikipedia

Amastatin

dynorphin A, and other endogenous peptides. It contains the unusual amino acid Statine. Bestatin Pepstatin Buckingham J (2 December 1993). "Amastatins". Dictionary

Pepstatin

aspartyl proteases. It is a hexa-peptide containing the unusual amino acid statine (Sta, (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid), having the sequence

Pepsin

pepstatin is thought to be responsible for pepstatin inhibition of pepsin; statine is a potential analog of the transition state for catalysis by pepsin and

Renin inhibitor

N-acyl-pentapeptide, more accurately: isovaleryl-L-valyl-L-valyl-statyl-L-alanyl-statine. Pepstatin was found to be a potent competitive inhibitor of most aspartic

Amprenavir

of these agents. This unit is closely related to the one found in the statine, an unusual amino acid that forms part of the pepstatin, a fermentation

C8H17NO3

The molecular formula C8H17NO3 may refer to: Desosamine Statine This set index page lists chemical structure articles associated with the same molecular

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October 2022. Retrieved 19 November 2012. "Polni.si :: Administracija modula statine strani". Archived from the original on 3 October 2022. Retrieved 19 November

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stuff and sharing it with others. Almanac, 55: 8. Rea, P.A. (2009) Les statines: de la moisissure aux médicaments. Pour la science, N°379, Mai 2009. "Dr