STT3B
Identifiers
AliasesSTT3B, CDG1X, SIMP, STT3-B, catalytic subunit of the oligosaccharyltransferase complex, STT3 oligosaccharyltransferase complex catalytic subunit B
External IDsOMIM: 608605; MGI: 1915542; HomoloGene: 7387; GeneCards: STT3B; OMA:STT3B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_178862

NM_024222

RefSeq (protein)

NP_849193

NP_077184

Location (UCSC)Chr 3: 31.53 – 31.64 MbChr 9: 115.07 – 115.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit STT3B is an enzyme that in humans is encoded by the STT3B gene.[5][6][7]

Function

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The STT3B protein contains a highly immunogenic minor histocompatibility antigen epitope of 9 amino acids, B6(dom1). Like ITM1 (MIM 601134), STT3B is homologous to yeast STT3, an oligosaccharyltransferase essential for cell proliferation.[8][7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163527Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032437Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R (July 2003). "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties". Molecular Cell. 12 (1): 101–11. doi:10.1016/S1097-2765(03)00243-0. PMID 12887896.
  6. ^ McBride K, Baron C, Picard S, Martin S, Boismenu D, Bell A, et al. (November 2002). "The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene". Immunogenetics. 54 (8): 562–9. doi:10.1007/s00251-002-0502-4. PMID 12439619. S2CID 25068432.
  7. ^ a b "Entrez Gene: STT3B STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)".
  8. ^ McBride K, Baron C, Picard S, Martin S, Boismenu D, Bell A, et al. (November 2002). "The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene". Immunogenetics. 54 (8). Springer Science and Business Media LLC: 562–9. doi:10.1007/s00251-002-0502-4. PMID 12439619. S2CID 25068432.

Further reading

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📚 Artikel Terkait di Wikipedia

Diabetes in Japan

showed that rs12630354 upregulates STT3B expression. This SNP causes significant STT3B expression in the adrenal gland. STT3B has been suggested to participate

Indocyanine green

antidote for the death cap mushroom toxin α-amanitin by inhibiting the enzyme STT3B. Cardiogreen at Sigma-Aldrich "Spy Agent Green APMDS". Therapeutic Goods

Oligosaccharyltransferase

OST is called STT3. Two paralogs exist in eukaryotes, termed STT3A and STT3B. STT3A is primarily responsible for cotranslational glycosylation of the

Chromosome 3

solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 STT3B: catalytic subunit of the oligosaccharyltransferase complex SYNPR: synaptoporin

STT3A, catalytic subunit of the oligosaccharyltransferase complex

Losfeld ME, Gilmore R, Freeze HH (November 2013). "Mutations in STT3A and STT3B cause two congenital disorders of glycosylation". Hum. Mol. Genet. 22 (22):

List of human protein-coding genes 8

Q9NRL3 16032 STS HGNC:11425; P08842 16033 STT3A HGNC:6172; P46977 16034 STT3B HGNC:30611; Q8TCJ2 16035 STUB1 HGNC:11427; Q9UNE7 16036 STUM HGNC:30491;