Alkaline ceramidase 2 juga dikenal sebagai ACER2 adalah enzim ceramidase yang pada manusia dikodekan oleh gen ACER2.[5]
Fungsi
suntingJalur ACER2/sphingosine memainkan peran penting dalam mengatur pematangan subunit integrin ฮฒ1 (ITGB1) dan adhesi sel yang dimediasi oleh integrin ฮฒ1.[6]
Referensi
sunting- ^ a b c GRCh38: Ensembl release 89: ENSG00000177076 โ Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038007 โ Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta. 1781 (9): 424โ34. doi:10.1016/j.bbalip.2008.06.002. PMCย 2614331. PMIDย 18619555.
- ^ Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009). "Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion". FASEB J. 23 (2): 656โ66. doi:10.1096/fj.08-115634. PMCย 2630785. PMIDย 18945876. Pemeliharaan CS1: DOI bebas tanpa ditandai (link)
Pranala luar
sunting- Lokasi genom ACER2 manusia dan halaman rincian gen ACER2 dalam UCSC Genome Browser.
Bacaan lanjutan
sunting- Xu R, Jin J, Hu W, etย al. (2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". FASEB J. 20 (11): 1813โ25. doi:10.1096/fj.05-5689com. PMIDย 16940153. S2CIDย 20973940. Pemeliharaan CS1: DOI bebas tanpa ditandai (link)
- Strausberg RL, Feingold EA, Grouse LH, etย al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899โ903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMCย 139241. PMIDย 12477932.
- Humphray SJ, Oliver K, Hunt AR, etย al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369โ74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMCย 2734081. PMIDย 15164053.
- Gerhard DS, Wagner L, Feingold EA, etย al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121โ7. doi:10.1101/gr.2596504. PMCย 528928. PMIDย 15489334.
- Wan D, Gong Y, Qin W, etย al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724โ9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMCย 524842. PMIDย 15498874.
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